Professor Muazzam Jacobs

Experimental Tuberculosis and Immunology Research Group

Professor Muazzam Jacobs PhD

Member, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town (UCT); National Health Laboratory Service (NHLS) Medical Scientist.

The Experimental Tuberculosis and Immunology Research Group forms part of the Division of Immunology, which is jointly affiliated to UCT and the NHLS.

Research areas of interest include understanding basic mechanisms of host immune function against tuberculosis (TB); and the evaluation of anti-TB therapy and therapeutic approaches. The group has significant skills and expertise in the application of in vitro cell culture and in vivo murine experimental models of TB, making extensive use of genetically modified mouse strains in which loss or gain of function studies can be performed. Research projects include investigating immune responses during pulmonary TB and central nervous system TB, and investigating efficacy of anti-mycobacterial lead compounds and drug delivery systems.


  • TNFR1 and TNFR2 in protective immunity against Mycobacterium tuberculosis (M. tb) infection
  • Tm-TNF and tuberculosis
  • Cell specific TNF and tuberculosis
  • Experimental tuberculosis meningitis
  • Orthopoxvirinae and MyD88

Selected publications:

See publications and profile on Research Gate.

Contact details:

Division of Immunology
Room S1.09, level 1, Wernher & Beit South
Institute of Infectious Disease and Molecular Medicine
Faculty of Health Sciences
University of Cape Town
Observatory 7925
South Africa

Tel:  +27 21 406 6078
Fax: +27 21 406 6078

Group members:

Members Position
Faried Abbas Laboratory Assistant
Nai-Jen Hsu Junior Research Fellow
Roanne Keeton Junior Research Fellow
Petr Konecny Postdoctoral Fellow
Antoinette Labuschagne PhD student
Sumayah Salie PhD student
Emily Tangie PhD student
Boipelo Sebesho PhD student
Khanyisile Kgoadi MSc student
Suhair Geyer MSc student
Phuti Choshi MSc student
Avril Walters MSc student
Buchule Mbobo  



Berhard Ryffel (Institute Transgenose, CNRS)

Valerie Quesniaux (Institute Transgenose, CNRS, France)

Don Mark Estes (University of Georgia, United States of America)

Stefan Magez (University of Vrije University, Belgium)

Gordon Brown (Aberdeen University)

Sergei Nedospasov (Deutchse-Rheuma Forschungzsentrum, Germany)

Irene Garcia   (University of Geneva, Switzerland)

George Kollias (Biomedical Sciences Research Centre "Alexander Flemming" Institute, Greece)


Anwar Jardine, (Department of Chemistry, UCT)

Lauriston Kellaway (Department of Human Biology, UCT)

Dirk Lang(Department of Human Biology, UCT)

Peter Folb (Medical Research Council)

Peter Smith (Department of Pharmacology, UCT)

Eliyah Madikane (Department of Medical Microbiology, UCT)

Paul van Helden (University of Stellenbosch)

Niresh Baghwandin Medical Research Council)