Professor Graeme Meintjes
Professor Graeme Meintjes MBChB (UCT) FRCP (Glasgow) FCP (SA) DipHIVMan (SA) MPH (Johns Hopkins) PhD (UCT)
Professor of Medicine; Second Chair and Deputy Head of the Department of Medicine, Faculty of Health Sciences, University of Cape Town (UCT); DST/NRF SARChI Chair in Poverty-related Infections; Adult Infectious Diseases Physician; Full Member; Institute of Infectious Disease and Molecular Medicine (IMD); lead of the Clinical Platform of the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa).
Graeme Meintjes leads a research programme that focuses on the clinical conditions affecting patients with advanced HIV disease including disseminated HIV-associated tuberculosis, the tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and cryptococcal meningitis. His group also investigates drug-resistant tuberculosis and diagnostics for TB, as well as prevention strategies for HIV and SARS-CoV-2. He has been the PI or local PI of several clinical trials, and conducts observational cohort studies that address questions related to disease pathogenesis. Graeme was principal investigator (PI) of the EDCTP-funded PredART trial that demonstrated that prednisone was effective and safe for the prevention of TB-IRIS in patients at high-risk starting ART (antiretroviral therapy), published in the New England Journal of Medicine in 2018. He is currently co-PI of the Wellcome-funded NEW STRAT TB trial investigating novel treatment strategies in patients admitted to hospital with disseminated HIV-associated TB.
He has contributed to the development of management guidelines for HIV, TB and cryptococcal meningitis at a provincial and national level and in WHO (World Health Organization) Guideline Development Groups. He is a Member of the Academy of Science of South Africa (ASSAf) and the College of Fellows of UCT, and holds a B1 rating from the National Research Foundation. He has been awarded Training (2007), Intermediate (2012) and Senior (2019) Fellowships by the Wellcome Trust. Graeme undertakes clinical work as a specialist at Groote Schuur Hospital and Khayelitsha Hospital. He also co-ordinates the undergraduate teaching programme of the Department of Medicine. He is the PI of the Fogarty HIV-associated TB Training Program held at UCT in partnership with Johns Hopkins and Vanderbilt Universities (http://www.hattp.uct.ac.za).
Selected publications:
See publications and profile on Research Gate.
Contact details:
Faculty of Health Sciences
Department of Medicine
J46.49 Old Main Building
Groote Schuur Hospital
University of Cape Town
Observatory, 7925
Tel: +27 21 406 6075 / 6201
Fax: +27 21 406 6796
Email: graeme.meintjes@uct.ac.za
Alternate sites: www.cidri.uct.ac.za
Group Members:
| Member | Position |
| NEW STRAT TB Trial | |
| Charlotte Schutz | Co-Principal Investigator |
| Phiona Namale | PhD student and lead investigator |
| Linda Boloko | PhD student and co-investigator |
| Fortunat Bagula | Research Medical Officer and co-investigator |
| Marcia Vermeulen | Research Medical Officer and co-investigator |
| Ida Oliphant | Research Nurse |
| Monica Toleni | Research Nurse |
| Ivy Apolisi | Research Nurse |
| Mkanyiseli Mpalali | Clinical Research Worker |
| Abulele Bekiswa | Lab Technologist |
| Gadisi Mthambeleni | Lab Technologist |
| HIV and SARS-CoV-2 prevention studies | |
| Amy Ward | Principal Investigator |
| Phillip du Preez | Research Medical Officer and co-investigator |
| Mandy Liao Rhodes | Research Medical Officer and co-investigator |
| Rene van der Venter | Regulatory Officer |
| Nwabisa Gom | Study Co-ordinator |
| Lebo Tseleka | Research Nurse |
| Nosipho Nombona | Research Nurse |
| Monica Magwayi | Counsellor |
| Nobom Masimini | Counsellor |
| Nonceba Gobe | Clinical Research Worker |
| Mzamo Ntanjana | Data Capturer |
| Nomvula Makade | Secretary |
| Bulelwa Mnyango | Community Liaison Officer |
| Phatuxolo Vinqishe | Community Health Worker |
| Sakhiwo Tunzi | Community Health Worker |
| Francisco Lakay | Site Laboratory Manager |
| ARTIST Trial | |
| Ying Zhao | PhD student and lead investigator |
| Zaayid Omar | Research Medical Officer and co-investigator |
| Zimasa Gcwabe | Study Co-ordinator |
| Matilda Nduna | Research Nurse |
| Sihle Nqina | Clinical Research Worker |
| Zimkitha Asare | Clinical Research Worker |
| EFFECT Trial | |
| Kyla Comins | Co-Principal Investigator |
| Richard Halley-Stott | Research Medical Officer and co-investigator |
| MAIT cells and TB studies | |
| Muki Shey | Principal Investigator |
| Avuyonke Balfour | PhD student |
| Noma Masina | PhD student |
| Rachel Dielle | Research Nurse |
| Fuzeka Mdudlwa | Clinical Research Worker |
| SHIFT-TB study | |
| Sean Wasserman | Co-Principal Investigator |
| Attie Stadler | PhD student and lead investigator |
| Sekelwa Dumile | Study Co-ordinator |
| Yolisa Sigila | Senior Research Nurse |
| Alfa Pitsha | Research Nurse |
| Kwanele Tyiki | Clinical Research Worker |
| PhD students | |
| Raymond Moseki | |
| Avuyonke Balfour | Co-supervisor |
| Rulan Griesel | Co-supervisor |
| Ying Zhao | |
| Phiona Namale | |
| Linda Boloko | |
| Kate Haigh | Co-supervisor |
| Attie Stadler | |
| Ashar Dhana | Co-supervisor |
| Ayanda Trevor Mnguni | Co-supervisor |
| Arifa Parker | Co-supervisor |
| Masters' students | |
| Siphiwe Baloyi | Co-supervisor |
| Josh Fieggan | Co-supervisor |
| Marcia Vermeulen | Co-supervisor |
| Herman Bagula | |
| Evashan Govender |
Collaborations:
International
Tom Harrison, St George's Hospital, London, United Kingdom (UK)
Sile Molloy, St George's Hospital, London, UK
Joseph Jarvis, London School of Tropical Medicine & Hygiene, UK
David Boulware, University of Minnesota, United States of America (USA)
David Meya, Makerere University, Uganda
Conrad Muzoora, Mbarara University, Uganda
Anne O'Garra, Francis Crick Institute, London, UK
James Brust, Albert Einstein College of Medicine, USA
Neel Gandhi, Emory University, USA
David Barr, University of Liverpool, UK
Rachel Lai, Imperial College London, UK
Elizabeth Phillips, Vanderbilt University Medical Center, USA
Mark Nicol, University of Western Australia, Australia
Fabrice Bonnet, University of Bordeaux, France
Local
Nelesh Govender, National Institute of Communicable Diseases
Robin Warren, Stellenbosch University
Mbulelo Mntonintshi, Walter Sisulu University
David Stead, Walter Sisulu University
* Only collaborators outside UCT are listed