Professor Stefan Barth

Medical Biotechnology & Immunotherapy Research Unit

Professor Stefan Barth MSc (Bonn) PhD (Bonn) DMSc (Cologne)

Tier 1 South African Research Chair in Cancer Biotechnology; Division of Chemical & Systems Biology; Department of Integrative Biomedical Sciences Member; Member and Executive Director, Medical Biotechnology and Immunotherapy Unit; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town.

The major aim of our research is the use of medical biotechnology methods including antibody technologies, protein engineering & expression, to develop and evaluate knowledge-based innovative recombinant immunodiagnostics and therapeutics. The main characteristics of these novel agents are: a) disease-specific activities, b) reduced unspecific side effects, and c) reduced immunogenicity.

Novel methods for selection of antibodies are developed in close collaboration with a) Dr. Mehmet K. Tur, Experimental Pathology and Immunotherapy, Institute for Pathology, University Hospital Giessen and Marburg, Germany, b) Dr Peter Duncan, Afrobodies, South Africa.

Novel fusion proteins will be designed using advanced supercomputing tools to model dynamic interactions of proteins, in close collaboration with Prof. Dr. Paolo Carloni, Institute for Advanced Simulation, Forschungszentrum Jülich, Germany.  Recombinant fusion proteins are mainly expressed in bacterial or mammalian cells and subsequently characterized in experimental settings, both in vitro on cell lines or primary material of patients and in vivo in transgenic/tumor-bearing mouse models.


Selected publications:

See publications and profile on Research Gate.


Contact details:

Department of Integrative Biomedical Sciences
Wernher & Beit North level 3
Institute of Infectious Disease and Molecular Medicine
Faculty of Health Sciences, University of Cape Town
Anzio Road
Observatory, 7925
South Africa

Tel: +27 21 406 6938 (office) 
Email: stefan.barth@uct.ac.za

Alternate site: http://www.chemsybio.uct.ac.za/csb/research/barth


Group members:

Member Position
Nyameka Mhlonyelwa-Mona Snr Secretary/Administration 
Olusiji Alex Akinrinmade Postdoctoral Fellow
Adebukola Kemi Daramola PhD Student
Anathi Nkayi PhD Student
Dennis Dogbey  PhD Student
Liyabona Mpondo PhD Student
Masala Mugeri PhD Student
Murithi Bernard Mirianga PhD Student
Siphelele Sanele Cingo PhD Student
Suzanne Hippolite Magagoum  PhD Student
Trishana Nundalall PhD Student
Ursula-Claire Andong-Koung-Edzizi PhD Student
Annestacia Marthinus MSc Student
Chardae Friedberg MSc Student
Emmanuel Adebowale Fajemisin  MSc Student
Grace Mayuni MSc Student
Jesmika Singh MSc Student
Marc Henry MSc Student
Maryam Karaan MSc Student
Salizwa Thinasithethi Malindi MSc Student
Sizalobuhle Masuku MSc Student
Stefane Motimele MSc Student
Takunda Ngwenya MSc Student
Tatenda Bvudzijena MSc Student
Valentine Amanda Shangase MSc Student
Gomolemo Atli Molope Honours Student
Dzunisani Phaweni CPUT WIL
Roschele Wilson CPUT WIL
Melissa Margarete Dorn Intern

Collaborations:
 


International
Dr Klaus Pors, University of Bradford, UK, Recombinant antibody drug conjugates
Dr Mehmet K. Tur, UKGM Giessen, Germany, Selection of antibodies on human cells/tissue
Dr Peter Duncan, Afrobodies, South Africa, Novel recombinant antibodies
Prof Andreas Maurer, University of Tübingen, Germany, Recombinant radiobiopharmaceuticals
Prof Matthias Peipp, University of Kiel, Germany, Therapeutically active fusion proteins
Prof Paolo Carloni, FZ Jülich, Germany, Simulation of dynamic protein interactions

Local
Prof Dirk Lang, UCT, Cape Town, Immunofluorescence Imaging
Prof Roger Hunter, UCT, Cape Town, Synthetic BG-modified SNAP substrates
Prof Ramona Hurdayal, UCT, Cape Town, Leishmania mouse models
Prof Komala Pillay, UCT, Cape Town, Access to NHLS FFPE patient sections
Prof Bert Klumperman, SUN, Stellenbosch, Synthetic BG-modified SNAP substrates