Associate Professor Sean Wasserman

Department of Medicine

A/Prof Sean Wasserman, MBChB, MMed (UCT), FCP (SA), Cert ID(Phys)SA, PhD

Consultant and Associate Professor, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital and University of Cape Town; Co-Lead of the Clinical Research Platform at the Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa); Associate Member, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town; Honorary Associate Professor, Faculty of Health and Life Sciences, University of Exeter; Member, MRC Centre for Medical Mycology, University of Exeter.

Sean Wasserman is an infectious diseases specialist based at Groote Schuur Hospital in Cape Town. His main research area is his main research area is treatment optimisation for tuberculosis and HIV-associated opportunistic infection. Sean is a pharmacologist on the ACTG Tuberculosis Transformative Science Group and a member of the NIH-CDC-HIVMA/IDSA Guidelines Committee for Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. 

Current major trials include PRESCIENT, a multi-center Phase 2c trial of an ultra-short regimen for drug- susceptible pulmonary TB (NCT05556746); REVIVE, a multi-country Phase 3 trial of azithromycin prophylaxis for advanced HIV (NCT05580666); and an ACTG study evaluating the use of double dose dolutegravir with rifapentine-based therapy for HIV-associated TB (NCT05630872). Sean is an investigator on the IMPRINT Fungal HIV Global Health Research Group where he leads a cohort study on pneumocystis pneumonia. He also leads a cohort study investigating predictors of treatment outcome for drug-resistant TB in the Eastern Cape Province of South Africa

Sean was a member of the original cohort of the International Society for Infectious Diseases (ISID) Emerging Leaders Program, and currently serves on the ISID Council. He was profiled by the Lancet journal as a ‘rising star in TB-HIV research and medicine’ and has received awards from the International Society for Infectious Diseases, the InterAcademy Partnership, and the International Union against Tuberculosis and Lung Disease, and Institut Mérieux and Infectious Diseases Society of Southern Africa.

Key areas of expertise: TB therapeutics, clinical trials, pneumocystis pneumonia

Selected publications:

See publications and profile on Research Gate.

Contact details:

Division of Infectious Diseases and HIV Medicine
Room G16.63, New Groote Schuur Hospital
Observatory 7925
South Africa

Tel:  +27 21 650 7220
Email:  / 

Other website links:
Infectious Diseases and HIV Medicine, University of Cape Town

Group members:

Member Position
Dr Attie Stadler PhD student
Dr Trevor Mnguni PhD student
Dr Nicola Wills MMed student
Dr Priya Arnab MMed student
Dr Benson Mudiwa MMed student
Dr Neil Hattingh  MSc student


Joe Jarvis and Joe Donovan (London School of Hygiene and Tropical Medicine, UK) 
Jay Kolls (Tulane University, US)
Rachel Lai (Imperial College London, UK)
Elin Svensson (Radboud Medical Centre, NL)
Grant Theron (Stellenbosch University, SA)